Slide 5: What was the pretreatment time with trehalose vs vehicle control? In Fig. 1, are left and right panels showing 6-OHDA treated cells with lower vs higher trehalose pretreatment? How were these trehalose conc. selected
Slide 8: What was the basis for the lower vs higher trehalose concentrations?
General comment: Does trehalose affect other signaling pathways, e.g. endogenous antioxidant defenses? See ref. Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways. Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y. Redox Biol. 2018 May;15:115-124. doi: 10.1016/j.redox.2017.09.007.
Does trehalose the cells?
Does trehalose enter the cells?
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